Genetic counselling of consanguineous fam il es 1 Use of Smith ' s method to calculate
نویسنده
چکیده
Smith (1971) described a method for deriving the recurrence risk of conditions with multifactorial inheritance in non-consanguineous families. In our paper the method is extended to those cases in which the parents are related. Some results are presented of specific examples in order to give some idea of the increased risk caused by consanguinity in some of the simple cases likely to be met in genetic counselling.
منابع مشابه
Genetic counseling of consanguineous families. Use of Smith's method to calculate recurrence risks in multifactorial inheritance in consanguineous matings.
A modification of Smith's method is described for deriving recurrence risks for multifactorial conditions when parents are related. Using cleft palate as an example, the possible increased risks caused by consanguinity are discussed.
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